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ATAXIA TELANGIECTASIA MUTATED PROTEINS
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DeCS
Descriptor
English
:
Ataxia Telangiectasia Mutated Proteins
Descriptor
Spanish
:
Proteínas de la Ataxia Telangiectasia Mutada
Descriptor
Portuguese
:
Proteínas Mutadas de Ataxia Telangiectasia
Tree Number:
D08.811.913.696.620.682.700.097
Definition
English
:
A group of
PROTEIN-SERINE-THREONINE KINASES
which activate critical signaling cascades in double strand breaks,
APOPTOSIS
, and GENOTOXIC STRESS such as ionizing ultraviolet A light, thereby acting as a
DNA damage
sensor. These
proteins
play a role in a wide range of signaling mechanisms in
cell cycle
control.
History Note
English
:
2014
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
55299
Unique Identifier:
D064007
Occurrence in VHL
:
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CID-10
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